Post by Admin on Jan 30, 2021 10:44:28 GMT
Prenatal Exposure to Psychotropic Medication Linked to Long Term Cognitive Impairment
School aged children exposed prenatally to psychotropic medication show poorer outcomes in cognitive ability
www.madinamerica.com/2017/08/prenatal-exposure-psychotropic-medication-linked-long-term-cognitive-impairment/
A new study, published in Acta Psychiatrica Scandinavica, investigates the long term impact of prenatal exposure to psychotropic medications on cognitive ability. The researchers identified outcomes that could serve as proxy measures for cognitive disabilities, such as requiring special needs education or attending special needs school, mental health diagnoses, and performance on final examinations. The results of the national follow-up study, conducted in Denmark, suggest that being exposed to psychotropic medications prenatally is associated with cognitive disabilities when children reach school age.
“Prenatal exposure to psychotropic drugs seems to affect cognitive abilities in the long term,” find the researchers, led by Morten Wibroe, from the Department of Pediatrics and Adolescent Medicine at Rigshospitalet in Copenhagen.
Original Article
Risk of impaired cognition after prenatal exposure to psychotropic drugs
M. A. Wibroe R. Mathiasen A. K. Pagsberg P. Uldall
First published: 31 May 2017 doi.org/10.1111/acps.12754Citations: 5
onlinelibrary.wiley.com/doi/full/10.1111/acps.12754
Abstract
Objective
Prenatal exposure to psychotropic drugs may affect the trajectories of brain development. In a register study, we investigated whether such exposure is associated with long‐term impaired cognitive abilities.
Method
Individuals born in Denmark in 1995–2008 were included. As proxies for cognitive impairment, requiring special needs education, attending special needs school, diagnoses of neurological/mental disorder, missed final examinations, and low school grade average were used. We accounted for maternal confounders.
Results
We identified 868 159 individuals of whom 13 983 (1.6%) were prenatally exposed. The adjusted odds ratio (OR) was 0.97[0.92–1.02] for requiring special needs education, 1.28[1.14–1.43] for attending special needs school, 1.32[1.20–1.46] for a neurological/mental disorder diagnosis, 1.37[1.22–1.54] for missing the final examinations, and 1.13[0.82–1.55] for obtaining a low school grade average. Exposure to psycholeptics (primarily antipsychotics and sedatives) was correlated with significantly increased risk for four outcomes. The highest was the risk of missing the primary school examinations (OR: 1.51[1.29–1.76]). The overall highest risk concerned the presence of a neurological/mental disorder after prenatal exposure to psychoanaleptics (primarily antidepressants) (OR: 1.86[1.24–2.78).
Conclusion
Prenatal exposure to psychotropic drugs affects proxy outcomes of cognitive disabilities at school age. Exposure to psycholeptics carries the largest risk. The role of psychoanaleptics is currently unclear.
School aged children exposed prenatally to psychotropic medication show poorer outcomes in cognitive ability
www.madinamerica.com/2017/08/prenatal-exposure-psychotropic-medication-linked-long-term-cognitive-impairment/
A new study, published in Acta Psychiatrica Scandinavica, investigates the long term impact of prenatal exposure to psychotropic medications on cognitive ability. The researchers identified outcomes that could serve as proxy measures for cognitive disabilities, such as requiring special needs education or attending special needs school, mental health diagnoses, and performance on final examinations. The results of the national follow-up study, conducted in Denmark, suggest that being exposed to psychotropic medications prenatally is associated with cognitive disabilities when children reach school age.
“Prenatal exposure to psychotropic drugs seems to affect cognitive abilities in the long term,” find the researchers, led by Morten Wibroe, from the Department of Pediatrics and Adolescent Medicine at Rigshospitalet in Copenhagen.
Original Article
Risk of impaired cognition after prenatal exposure to psychotropic drugs
M. A. Wibroe R. Mathiasen A. K. Pagsberg P. Uldall
First published: 31 May 2017 doi.org/10.1111/acps.12754Citations: 5
onlinelibrary.wiley.com/doi/full/10.1111/acps.12754
Abstract
Objective
Prenatal exposure to psychotropic drugs may affect the trajectories of brain development. In a register study, we investigated whether such exposure is associated with long‐term impaired cognitive abilities.
Method
Individuals born in Denmark in 1995–2008 were included. As proxies for cognitive impairment, requiring special needs education, attending special needs school, diagnoses of neurological/mental disorder, missed final examinations, and low school grade average were used. We accounted for maternal confounders.
Results
We identified 868 159 individuals of whom 13 983 (1.6%) were prenatally exposed. The adjusted odds ratio (OR) was 0.97[0.92–1.02] for requiring special needs education, 1.28[1.14–1.43] for attending special needs school, 1.32[1.20–1.46] for a neurological/mental disorder diagnosis, 1.37[1.22–1.54] for missing the final examinations, and 1.13[0.82–1.55] for obtaining a low school grade average. Exposure to psycholeptics (primarily antipsychotics and sedatives) was correlated with significantly increased risk for four outcomes. The highest was the risk of missing the primary school examinations (OR: 1.51[1.29–1.76]). The overall highest risk concerned the presence of a neurological/mental disorder after prenatal exposure to psychoanaleptics (primarily antidepressants) (OR: 1.86[1.24–2.78).
Conclusion
Prenatal exposure to psychotropic drugs affects proxy outcomes of cognitive disabilities at school age. Exposure to psycholeptics carries the largest risk. The role of psychoanaleptics is currently unclear.